position: EnglishChannel > Sci-Tech News > Article

Shanghai institute shares all SARS-CoV-2 expression plasmids

Source: International Communication Center for Science & Technology| 2020-06-24 14:26:59| Author: Wang Chuan& China.org

A staff member displays samples of the COVID-19 inactivated vaccine at Sinovac Biotech Ltd., in Beijing, capital of China, March 16, 2020. [Photo/Xinhua]

On June 17, the National Center for Protein Science Shanghai made expression plasmids of all 29 proteins encoded by SARS-CoV-2 available to scientists around the world through a Protein Bank Program (PBP), according to the Shanghai Advanced Research Institute of the Chinese Academy of Sciences.

Rao Zihe, an academician of the Chinese Academy of Sciences, and other researchers led the research on the expression plasmids of all 29 proteins encoded by SARS-CoV-2, the virus that causes COVID-19.

The study of the 29 proteins is crucial to the analysis of pathogenic mechanism, vaccine development, reagent detection, and antibody and drug development.

Experts said the first phase of the PBP is mainly focused on a protein expression plasmid bank, which provides the storage and delivery service of protein expression plasmids. The COVID-19 virus genome consists of less than 30,000 bases and can encodes 29 proteins, including 16 non-structural proteins, four structural proteins and nine auxiliary proteins. Among them, NSP7, NSP8, and NSP12 (all three are non-structural proteins) form RNA-dependent RNA polymerase complexes, which play an important role in virus replication and transcription cycle. NSP5, a 3C proteolytic enzyme, can liberate most other NSP proteins from the protein chain, and is considered to be an important target for the research of antivirus drugs. Four structural proteins, S, E, M, and N, form the outer layer of the coronavirus and protect the internal RNA, in which the spike (S) protein can help the virus invade cells.

To increase China's capabilities of responding to public health crisis, the Shanghai Advanced Research Institute of the Chinese Academy of Sciences established the Protein Bank Program.

(You can also read it at: http://www.china.org.cn/china/2020-06/24/content_76198185.htm)

Editor:龙云

Top News

  • China launched the last satellite of the BeiDou Navigation Satellite System (BDS) on June 23, marking the completion of the deployment of its own global navigation system.

Researchers discover mechanism that makes COVID-19 more severe in diabetics

Brazilian researchers have discovered one of the causes of severe COVID-19 in diabetic patients. Laboratory experiments showed that the higher level of blood sugar in these patients is captured by monocytes, a type of defense cell, and serves as a source of additional energy for the coronavirus to replicate more than in a healthy organism. In response to the increased viral load, the monocytes release large amounts of pro-inflammatory cytokines with several effects including lung cell death.

A Future to Expect: International S&T Community Expresses High Hope in Cooperation with Peers in China English

According to the latest news from Science and Technology Daily (April 14th), two COVID-19 inactivated vaccines were just approved for a phase I & II combined clinical trial by the National Medical Products Administration (NMPA) of China, making them the first batch in this category. The two vaccines were developed respectively by Wuhan Institute of Biological Products Co., Ltd of Sinopharm and Sinovac Research & Development Co., Ltd together with research institutes.

Copyright © Science and Technology Daily, All Rights Reserved

mailto: yuhy@stdaily.com