As the Lancang-Mekong Cooperation (LMC) mechanism, initiated by the six countries of the region in 2016 to build a community with a shared future of peace and prosperity, marks its 10th anniversary, regional science and technology innovation cooperation has improved vastly. Multiple fields show substantive results, including aerospace, agriculture, water resource management and digital technology.

China continues implementing the Lancang-Mekong Space Cooperation Plan with Mekong countries. It launched the "Fudan-1 Lancang-Mekong Future Star" in 2024, and supported Fudan University in establishing the Research Center for Lancang-Mekong Youth Astronomical Sciences, an important platform for the six countries for exchange and cooperation in space observation and technology application.

Chinese agricultural technology has contributed to poverty reduction and industrial transformation in the region.

For example, the Spice and Beverage Research Institute of the Chinese Academy of Tropical Agricultural Sciences (CATAS) has collaborated with the  Lancang-Mekong Agricultural Cooperation Center to promote disease-resistant cultivation techniques in Cambodia, which increased the local pepper production by over 22 percent and annual income of farmers by 1,000 USD. This project was listed as one of the global best poverty reduction practices.

The Rubber Research Institute of CATAS, cooperating with institutions from Mekong countries, has launched a demonstration project on rubber tree cultivation and processing techniques to reduce environmental pollution and damage to trees while helping upgrade the regional rubber industry.

The sustainable management and utilization of water resources is another important cooperation field. The six countries have established the Lancang-Mekong Water Resources Cooperation Center and an information sharing platform, applying advanced technologies for climate change mitigation and adaptation, disaster management, hydrological data monitoring and sharing, and water-related infrastructure construction.

For innovation-driven development and bridging the digital divide, the Lancang-Mekong countries accelerated the implementation of the Joint Initiatives on the LMC Innovation Corridor Development. China has proposed establishing a computing-infrastructure cooperation network with Mekong countries based on the Lancang-Mekong Cloud Computing Innovation Center to support regional AI capacity building and digital development.

To facilitate the integration of the regional digital economy, the six countries jointly released an initiative on technology cooperation for cross-border data flows in November 2025. It aims to improve data governance, digital infrastructure, AI and blockchain technology R&D as well as applications.